The story revolves around a group of college friends who retreat to a remote cabin for a weekend getaway. Their vacation takes a turn for the worse when a chemical spill from a nearby industrial plant contaminates a local beaver pond. The contaminated water turns the beavers into zombie-like creatures with a taste for human flesh.

As the zombified beavers begin to attack, the group must fend for themselves against these unusual and dangerous adversaries. The film mixes slapstick humor with gory horror, creating a blend of comedy and terror.